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pentobarbital decreases effects of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Coadministration of CYP3A4 inducers may well lessen sufentanil ranges and efficacy, probably precipitating withdrawal syndrome in individuals who've formulated physical dependence to sufentanil. Disconti